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    February 2008
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  • What I said before

all in the day…

SO you may be wondering why? why? WHY? is she thinking Cushings Disease/Syndrome…well let’s go with this…

From Wiki:

is an endocrine disorder caused by high levels of cortisol in the blood from a variety of causes, including a pituitary adenoma (known as Cushing’s disease), adrenal hyperplasia or neoplasia, ectopic ACTH production (e.g., from a small cell lung cancer), and iatrogenic (steroid use). Normally, cortisol is released from the adrenal gland in response to ACTH being released from the pituitary gland. Both Cushing’s syndrome and Cushing’s disease are characterized by elevated levels of cortisol in the blood, but the cause of elevated cortisol differs between the two. Cushing’s disease specifically refers to a tumour in the pituitary gland that stimulates excessive release of cortisol from the adrenal gland by releasing large amounts of ACTH. In Cushing’s disease, ACTH levels do not respond to negative feedback from the high levels of cortisol.

and some symptoms…

Symptoms include rapid weight gain, particularly of the trunk and face with sparing of the limbs (central obesity), ME a round face often referred to as a “moon face“, ME excess sweating, ME telangiectasia (dilation of capillaries), thinning of the skin (which causes easy bruising) and other mucous membranes, purple or red striae (the weight gain in Cushing’s stretches the skin, which is thin and weakened, causing it to hemorrhage) on the trunk, buttocks, arms, legs or breasts, proximal muscle weakness (hips, shoulders) ME, and hirsutism (facial male-pattern hair growth). A common sign is the growth of fat pads along the collar bone and on the back of the neck (known as a lipodystrophy)ME. The excess cortisol may also affect other endocrine systems and cause, for example, ME mild insomnia, MEreduced libido, impotence, amenorrhoea and ME infertility. Patients frequently suffer various psychological disturbances, ranging from euphoria to psychosis. ME Depression and ME anxiety are also common.[2]

Other signs include persistent ME hypertension (due to cortisol’s enhancement of epinephrine‘s vasoconstrictive effect) and insulin resistance (especially common in ectopic ACTH production), leading to hyperglycemia (high blood sugars) which can lead to diabetes mellitus. Untreated Cushing’s syndrome can lead to heart disease and increased mortality. Cushing’s syndrome due to excess ACTHmineralcorticoid activity in high concentrations, worsening the hypertension and leading to hypokalemiagastrointestinal may also result in hyperpigmentation. This is due to Melanocyte-Stimulating Hormone production as a byproduct of ACTH synthesis from Proopiomelanocortin (POMC). Cortisol can also exhibit (common in ectopic ACTH secretion). Furthermore, disturbances, opportunistic infections and impaired wound healing (cortisol is a stress hormone, so it depresses the immune and inflammatory responses). Osteoporosis is also problem in Cushing’s Syndrome since, as mentioned before, cortisol evokes a stress-like response. The body’s maintenance of bone (and other tissues) is therefore no longer one of its main priorities, so to speak.

So I was thinking that since I had 90% of the common symptoms and have several other less common symptoms and that I have been diagnosed with PCOS…this might be what keeps me in an unhealthy state…

so a long post mostly cut and pasted but very full of information…maybe more then you wanted!!

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One Response

  1. I googled this yesterday after reading your doctor post and it does sound like it could be. Do you already have an endocrinologist or justa rheumatologist? Hopefully you can get the testing you need to determine if this is the problem.

    Fingers crossed!

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